1s17

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{{STRUCTURE_1s17| PDB=1s17 | SCENE= }}
{{STRUCTURE_1s17| PDB=1s17 | SCENE= }}
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'''Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors'''
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===Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors===
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==Overview==
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Screening of our compound collection using Staphylococcus aureus Ni-Peptide deformylase (PDF) afforded a very potent PDF inhibitor with an IC(50) in the low nanomolar range but with poor antibacterial activity (MIC). Three-dimensional structural information obtained from Pseudomonas aeruginosa Ni-PDF complexed with the inhibitor suggested the synthesis of a variety of analogues that would maintain high binding affinity while attempting to improve antibacterial activity. Many of the compounds synthesized proved to be excellent PDF-Ni inhibitors and some showed increased antibacterial activity in selected strains.
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(as it appears on PubMed at http://www.pubmed.gov), where 15006385 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15006385}}
==About this Structure==
==About this Structure==
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[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
[[Category: Rational drug design]]
[[Category: Rational drug design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:09:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:49:33 2008''

Revision as of 17:49, 28 July 2008

Image:1s17.png

Template:STRUCTURE 1s17

Identification of Novel Potent Bicyclic Peptide Deformylase Inhibitors

Template:ABSTRACT PUBMED 15006385

About this Structure

1S17 is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Identification of novel potent bicyclic peptide deformylase inhibitors., Molteni V, He X, Nabakka J, Yang K, Kreusch A, Gordon P, Bursulaya B, Warner I, Shin T, Biorac T, Ryder NS, Goldberg R, Doughty J, He Y, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1477-81. PMID:15006385

Page seeded by OCA on Mon Jul 28 20:49:33 2008

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