2a3j

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[[Image:2a3j.gif|left|200px]]
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{{STRUCTURE_2a3j| PDB=2a3j | SCENE= }}
{{STRUCTURE_2a3j| PDB=2a3j | SCENE= }}
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'''Structure of URNdesign, a complete computational redesign of human U1A protein'''
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===Structure of URNdesign, a complete computational redesign of human U1A protein===
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==Overview==
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Achieving atomic-level resolution in the computational design of a protein structure remains a challenging problem despite recent progress. Rigorous experimental tests are needed to improve protein design algorithms, yet studies of the structure and dynamics of computationally designed proteins are very few. The NMR structure and backbone dynamics of a redesigned protein of 96 amino acids are compared here with the design target, human U1A protein. We demonstrate that the redesigned protein reproduces the target structure to within the uncertainty of the NMR coordinates, even as 65 out of 96 amino acids were simultaneously changed by purely computational methods. The dynamics of the backbone of the redesigned protein also mirror those of human U1A, suggesting that the protein design algorithm captures the shape of the potential energy landscape in addition to the local energy minimum.
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{{ABSTRACT_PUBMED_16698546}}
==About this Structure==
==About this Structure==
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2A3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3J OCA].
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2A3J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3J OCA].
==Reference==
==Reference==
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[[Category: Rrm]]
[[Category: Rrm]]
[[Category: U1a]]
[[Category: U1a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:33:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:51:11 2008''

Revision as of 17:51, 28 July 2008

Image:2a3j.png

Template:STRUCTURE 2a3j

Structure of URNdesign, a complete computational redesign of human U1A protein

Template:ABSTRACT PUBMED 16698546

About this Structure

2A3J is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

High-resolution structural validation of the computational redesign of human U1A protein., Dobson N, Dantas G, Baker D, Varani G, Structure. 2006 May;14(5):847-56. PMID:16698546

Page seeded by OCA on Mon Jul 28 20:51:11 2008

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