2f44

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{{STRUCTURE_2f44| PDB=2f44 | SCENE= }}
{{STRUCTURE_2f44| PDB=2f44 | SCENE= }}
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'''Crystal Structure of the Zinc-bound Shank SAM domain'''
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===Crystal Structure of the Zinc-bound Shank SAM domain===
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==Overview==
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The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_16439662}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16439662 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16439662}}
==About this Structure==
==About this Structure==
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[[Category: Shank]]
[[Category: Shank]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:26:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:54:28 2008''

Revision as of 17:54, 28 July 2008

Image:2f44.png

Template:STRUCTURE 2f44

Crystal Structure of the Zinc-bound Shank SAM domain

Template:ABSTRACT PUBMED 16439662

About this Structure

2F44 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662

Page seeded by OCA on Mon Jul 28 20:54:28 2008

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