1xn0

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{{STRUCTURE_1xn0| PDB=1xn0 | SCENE= }}
{{STRUCTURE_1xn0| PDB=1xn0 | SCENE= }}
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'''Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram'''
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===Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram===
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==Overview==
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Phosphodiesterases (PDEs) comprise a large family of enzymes that catalyze the hydrolysis of cAMP or cGMP and are implicated in various diseases. We describe the high-resolution crystal structures of the catalytic domains of PDE4B, PDE4D, and PDE5A with ten different inhibitors, including the drug candidates cilomilast and roflumilast, for respiratory diseases. These cocrystal structures reveal a common scheme of inhibitor binding to the PDEs: (i) a hydrophobic clamp formed by highly conserved hydrophobic residues that sandwich the inhibitor in the active site; (ii) hydrogen bonding to an invariant glutamine that controls the orientation of inhibitor binding. A scaffold can be readily identified for any given inhibitor based on the formation of these two types of conserved interactions. These structural insights will enable the design of isoform-selective inhibitors with improved binding affinity and should facilitate the discovery of more potent and selective PDE inhibitors for the treatment of a variety of diseases.
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{{ABSTRACT_PUBMED_15576036}}
==About this Structure==
==About this Structure==
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[[Category: Phosphodiesterase]]
[[Category: Phosphodiesterase]]
[[Category: Rolipram]]
[[Category: Rolipram]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:14:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:55:49 2008''

Revision as of 17:55, 28 July 2008

Image:1xn0.png

Template:STRUCTURE 1xn0

Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram

Template:ABSTRACT PUBMED 15576036

About this Structure

1XN0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the activity of drugs that inhibit phosphodiesterases., Card GL, England BP, Suzuki Y, Fong D, Powell B, Lee B, Luu C, Tabrizizad M, Gillette S, Ibrahim PN, Artis DR, Bollag G, Milburn MV, Kim SH, Schlessinger J, Zhang KY, Structure. 2004 Dec;12(12):2233-47. PMID:15576036

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