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1uqr
From Proteopedia
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(New page: 200px<br /> <applet load="1uqr" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uqr, resolution 1.7Å" /> '''TYPE II 3-DEHYDROQUI...)
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Revision as of 18:32, 29 October 2007
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TYPE II 3-DEHYDROQUINATE DEHYDRATASE (DHQASE) FROM ACTINOBACILLUS PLEUROPNEUMONIAE
Overview
The structure of the type II dehydroquinate dehydratase (DHQase) from, Actinobacillus pleuropneumoniae, the third enzyme of the shikimate, pathway, has been determined. Crystals diffracting to 1.7 A were obtained, in space and on earth using the counter-diffusion technique. The structure, was solved using molecular replacement and refined to high resolution. The, overall structure of the dodecameric enzyme is described and compared with, structures of DHQases from other bacteria. DHQases contain a flexible loop, that presumably closes over the active site upon substrate binding. The, enzyme can exist in an open or closed conformation. The present structure, displays the open conformation, with a sulfate anion bound in the active, site. The availability of this structure opens a route to ... [(full description)]
About this Structure
1UQR is a [Single protein] structure of sequence from [Actinobacillus pleuropneumoniae] with SO4 and TRS as [ligands]. Active as [[1]], with EC number [4.2.1.10]. Full crystallographic information is available from [OCA].
Reference
Structural study of the type II 3-dehydroquinate dehydratase from Actinobacillus pleuropneumoniae., Maes D, Gonzalez-Ramirez LA, Lopez-Jaramillo J, Yu B, De Bondt H, Zegers I, Afonina E, Garcia-Ruiz JM, Gulnik S, Acta Crystallogr D Biol Crystallogr. 2004 Mar;60(Pt 3):463-71. Epub 2004, Feb 25. PMID:14993670
Page seeded by OCA on Mon Oct 29 20:37:21 2007
