1p5h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1p5h.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1p5h.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1p5h| PDB=1p5h | SCENE= }}
{{STRUCTURE_1p5h| PDB=1p5h | SCENE= }}
-
'''Crystal structure of Formyl-CoA Transferase (apoenzyme) from Oxalobacter formigenes'''
+
===Crystal structure of Formyl-CoA Transferase (apoenzyme) from Oxalobacter formigenes===
-
==Overview==
+
<!--
-
Formyl-CoA transferase catalyses transfer of CoA from formate to oxalate in the first step of oxalate degradation by Oxalobacter formigenes, a bacterium present in the intestinal flora which is implicated in oxalate catabolism in mammals. Formyl-CoA transferase is a member of a family of CoA-transferases for which no structural information is available. We now report the three-dimensional structure of O.formigenes formyl-CoA transferase, which reveals a novel fold and a very striking assembly of the homodimer. The subunit is composed of a large and a small domain where residues from both the N- and C-termini of the subunit are part of the large domain. The linkers between the domains give the subunit a circular shape with a hole in the middle. The enzyme monomers are tightly interacting and are interlocked. This fold requires drastic rearrangement of approximately 75 residues at the C-terminus for formation of the dimer. The structure of a complex of formyl-CoA transferase with CoA is also reported and sets the scene for a mechanistic understanding of enzymes of this family of CoA-transferases.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12839984}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12839984 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12839984}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Oxalate]]
[[Category: Oxalate]]
[[Category: Oxalate degradation]]
[[Category: Oxalate degradation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:42:41 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:57:46 2008''

Revision as of 17:57, 28 July 2008

Image:1p5h.png

Template:STRUCTURE 1p5h

Crystal structure of Formyl-CoA Transferase (apoenzyme) from Oxalobacter formigenes

Template:ABSTRACT PUBMED 12839984

About this Structure

1P5H is a Single protein structure of sequence from Oxalobacter formigenes. Full crystallographic information is available from OCA.

Reference

Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer., Ricagno S, Jonsson S, Richards N, Lindqvist Y, EMBO J. 2003 Jul 1;22(13):3210-9. PMID:12839984

Page seeded by OCA on Mon Jul 28 20:57:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1p5h"
Personal tools