1v9u

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[[Image:1v9u.gif|left|200px]]
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{{Seed}}
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[[Image:1v9u.png|left|200px]]
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{{STRUCTURE_1v9u| PDB=1v9u | SCENE= }}
{{STRUCTURE_1v9u| PDB=1v9u | SCENE= }}
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'''Human Rhinovirus 2 bound to a fragment of its cellular receptor protein'''
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===Human Rhinovirus 2 bound to a fragment of its cellular receptor protein===
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==Overview==
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Although many viral receptors have been identified, the ways in which they interact with their cognate viruses are not understood at the molecular level. We have determined the X-ray structure of a complex between calcium-containing modules of the very low-density lipoprotein receptor and the minor group human rhinovirus HRV2. The receptor binds close to the icosahedral five-fold vertex, with only one module per virus protomer. The binding face of this module is defined by acidic calcium-chelating residues and, in particular, by an exposed tryptophan that is highly conserved. The attachment site on the virus involves only residues from VP1, particularly a lysine strictly conserved in all minor group HRVs. The disposition of the attached ligand-binding repeats around the five-fold axis, together with the proximity of the N- and C-terminal ends of adjacent modules, suggests that more than one repeat in a single receptor molecule might attach simultaneously.
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The line below this paragraph, {{ABSTRACT_PUBMED_15064754}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15064754 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15064754}}
==About this Structure==
==About this Structure==
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[[Category: Virus-protein complex]]
[[Category: Virus-protein complex]]
[[Category: Vldl-receptor]]
[[Category: Vldl-receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:16:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:59:01 2008''

Revision as of 17:59, 28 July 2008

Image:1v9u.png

Template:STRUCTURE 1v9u

Human Rhinovirus 2 bound to a fragment of its cellular receptor protein

Template:ABSTRACT PUBMED 15064754

About this Structure

1V9U is a Protein complex structure of sequences from Homo sapiens and Human rhinovirus 2. Full crystallographic information is available from OCA.

Reference

X-ray structure of a minor group human rhinovirus bound to a fragment of its cellular receptor protein., Verdaguer N, Fita I, Reithmayer M, Moser R, Blaas D, Nat Struct Mol Biol. 2004 May;11(5):429-34. Epub 2004 Apr 4. PMID:15064754

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