2hlb

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{{STRUCTURE_2hlb| PDB=2hlb | SCENE= }}
{{STRUCTURE_2hlb| PDB=2hlb | SCENE= }}
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'''A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity'''
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===A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity===
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==Overview==
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Heterotrimeric G proteins are molecular switches that relay information intracellularly in response to various extracellular signals. How ligand-activated G protein-coupled receptors act at a distance to exert exchange activity on the Galpha nucleotide binding pocket is poorly understood. Here we describe the synergistic action of two peptides: one from the third intracellular loop of the D2 dopamine receptor (D2N), and a second, Galpha.GDP-binding peptide (KB-752) that mimics the proposed role of Gbetagamma in receptor-promoted nucleotide exchange. The structure of both peptides in complex with Galpha(i1) suggests that conformational changes in the beta3/alpha2 loop and beta6 strand act in concert for efficient nucleotide exchange. Two key residues in the alpha4 helix were found to define a receptor/Galpha(i) coupling specificity determinant.
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(as it appears on PubMed at http://www.pubmed.gov), where 17264214 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17264214}}
==About this Structure==
==About this Structure==
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[[Category: Watts, V J.]]
[[Category: Watts, V J.]]
[[Category: Protein:peptide complex]]
[[Category: Protein:peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:25:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:59:36 2008''

Revision as of 17:59, 28 July 2008

Image:2hlb.png

Template:STRUCTURE 2hlb

A Structural Basis for Nucleotide Exchange on G-alpha-i Subunits and Receptor Coupling Specificity

Template:ABSTRACT PUBMED 17264214

About this Structure

2HLB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity., Johnston CA, Siderovski DP, Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

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