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1wq6

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[[Image:1wq6.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1wq6| PDB=1wq6 | SCENE= }}
{{STRUCTURE_1wq6| PDB=1wq6 | SCENE= }}
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'''The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity'''
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===The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity===
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==Overview==
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AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules.
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(as it appears on PubMed at http://www.pubmed.gov), where 16616331 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16616331}}
==About this Structure==
==About this Structure==
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[[Category: Eto]]
[[Category: Eto]]
[[Category: Nhr2]]
[[Category: Nhr2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:00:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:00:33 2008''

Revision as of 18:00, 28 July 2008

Image:1wq6.png

Template:STRUCTURE 1wq6

The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO'S activity

Template:ABSTRACT PUBMED 16616331

About this Structure

1WQ6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity., Liu Y, Cheney MD, Gaudet JJ, Chruszcz M, Lukasik SM, Sugiyama D, Lary J, Cole J, Dauter Z, Minor W, Speck NA, Bushweller JH, Cancer Cell. 2006 Apr;9(4):249-60. PMID:16616331

Page seeded by OCA on Mon Jul 28 21:00:33 2008

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