1wje

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[[Image:1wje.gif|left|200px]]
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{{STRUCTURE_1wje| PDB=1wje | SCENE= }}
{{STRUCTURE_1wje| PDB=1wje | SCENE= }}
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'''SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE'''
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===SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The solution structure of His12 --&gt; Cys mutant of the N-terminal zinc binding domain (residues 1-55; IN(1-55)) of HIV-1 integrase complexed to cadmium has been solved by multidimensional heteronuclear NMR spectroscopy. The overall structure is very similar to that of the wild-type N-terminal domain complexed to zinc. In contrast to the wild-type domain, however, which exists in two interconverting conformational states arising from different modes of coordination of the two histidine side chains to the metal, the cadmium complex of the His12 --&gt; Cys mutant exists in only a single form at low pH. The conformation of the polypeptide chain encompassing residues 10-18 is intermediate between the two forms of the wild-type complex.
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(as it appears on PubMed at http://www.pubmed.gov), where 9865962 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9865962}}
==About this Structure==
==About this Structure==
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1WJE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJE OCA].
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1WJE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJE OCA].
==Reference==
==Reference==
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[[Category: Polyprotein]]
[[Category: Polyprotein]]
[[Category: Zn-binding protein]]
[[Category: Zn-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:45:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:01:40 2008''

Revision as of 18:01, 28 July 2008

Image:1wje.png

Template:STRUCTURE 1wje

SOLUTION STRUCTURE OF H12C MUTANT OF THE N-TERMINAL ZN BINDING DOMAIN OF HIV-1 INTEGRASE COMPLEXED TO CADMIUM, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9865962

About this Structure

1WJE is a Single protein structure of sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

Solution structure of the His12 --> Cys mutant of the N-terminal zinc binding domain of HIV-1 integrase complexed to cadmium., Cai M, Huang Y, Caffrey M, Zheng R, Craigie R, Clore GM, Gronenborn AM, Protein Sci. 1998 Dec;7(12):2669-74. PMID:9865962

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