This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hr7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2hr7.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2hr7.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2hr7| PDB=2hr7 | SCENE= }}
{{STRUCTURE_2hr7| PDB=2hr7 | SCENE= }}
-
'''Insulin receptor (domains 1-3)'''
+
===Insulin receptor (domains 1-3)===
-
==Overview==
+
<!--
-
The insulin receptor (IR) and the type-1 insulin-like growth factor receptor (IGF1R) are homologous multidomain proteins that bind insulin and IGF with differing specificity. Here we report the crystal structure of the first three domains (L1-CR-L2) of human IR at 2.3 A resolution and compare it with the previously determined structure of the corresponding fragment of IGF1R. The most important differences seen between the two receptors are in the two regions governing ligand specificity. The first is at the corner of the ligand-binding surface of the L1 domain, where the side chain of F39 in IR forms part of the ligand binding surface involving the second (central) beta-sheet. This is very different to the location of its counterpart in IGF1R, S35, which is not involved in ligand binding. The second major difference is in the sixth module of the CR domain, where IR contains a larger loop that protrudes further into the ligand-binding pocket. This module, which governs IGF1-binding specificity, shows negligible sequence identity, significantly more alpha-helix, an additional disulfide bond, and opposite electrostatic potential compared to that of the IGF1R.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16894147}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16894147 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16894147}}
==Disease==
==Disease==
Line 31: Line 35:
[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:36:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:04:10 2008''

Revision as of 18:04, 28 July 2008

Image:2hr7.png

Template:STRUCTURE 2hr7

Contents

Insulin receptor (domains 1-3)

Template:ABSTRACT PUBMED 16894147

Disease

Known disease associated with this structure: Diabetes mellitus, insulin-resistant, with acanthosis nigricans OMIM:[147670], Hyperinsulinemic hypoglycemia, familial, 5 OMIM:[147670], Leprechaunism OMIM:[147670], Rabson-Mendenhall syndrome OMIM:[147670]

About this Structure

2HR7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity., Lou M, Garrett TP, McKern NM, Hoyne PA, Epa VC, Bentley JD, Lovrecz GO, Cosgrove LJ, Frenkel MJ, Ward CW, Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34. Epub 2006 Aug 7. PMID:16894147

Page seeded by OCA on Mon Jul 28 21:04:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hr7"
Personal tools