3cf0

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{{STRUCTURE_3cf0| PDB=3cf0 | SCENE= }}
{{STRUCTURE_3cf0| PDB=3cf0 | SCENE= }}
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'''Structure of D2 subdomain of P97/VCP in complex with ADP'''
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===Structure of D2 subdomain of P97/VCP in complex with ADP===
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==Overview==
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The ATPases associated with various cellular activities (AAA) protein p97 has been implicated in a variety of cellular processes, including endoplasmic reticulum-associated degradation and homotypic membrane fusion. p97 belongs to a subgroup of AAA proteins that contains two nucleotide binding domains, D1 and D2. We determined the crystal structure of D2 at 3.0 A resolution. This model enabled rerefinement of full-length p97 in different nucleotide states against previously reported low-resolution diffraction data to significantly improved R values and Ramachandran statistics. Although the overall fold remained similar, there are significant improvements, especially around the D2 nucleotide binding site. The rerefinement illustrates the importance of knowledge of high-resolution structures of fragments covering most of the whole molecule. The structures suggest that nucleotide hydrolysis is transformed into larger conformational changes by pushing of one D2 domain by its neighbor in the hexamer, and transmission of nucleotide-state information through the D1-D2 linker to displace the N-terminal, effector binding domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 18462676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18462676}}
==About this Structure==
==About this Structure==
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[[Category: Transport protein]]
[[Category: Transport protein]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:37:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:06:47 2008''

Revision as of 18:06, 28 July 2008

Image:3cf0.png

Template:STRUCTURE 3cf0

Structure of D2 subdomain of P97/VCP in complex with ADP

Template:ABSTRACT PUBMED 18462676

About this Structure

3CF0 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change., Davies JM, Brunger AT, Weis WI, Structure. 2008 May;16(5):715-26. PMID:18462676

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