1r5c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r5c.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1r5c.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r5c| PDB=1r5c | SCENE= }}
{{STRUCTURE_1r5c| PDB=1r5c | SCENE= }}
-
'''X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)'''
+
===X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)===
-
==Overview==
+
<!--
-
Bovine seminal ribonuclease (BS-RNase) is a unique member of the pancreatic-like ribonuclease superfamily. This enzyme exists as two conformational isomers with distinctive biological properties. The structure of the major isomer is characterized by the swapping of the N-terminal segment (MxM BS-RNase). In this article, the crystal structures of the ligand-free MxM BS-RNase and its complex with 2'-deoxycitidylyl(3',5')-2'-deoxyadenosine derived from isomorphous crystals have been refined. Interestingly, the comparison between this novel ligand-free form and the previously published sulfate-bound structure reveals significant differences. In particular, the ligand-free MxM BS-RNase is closer to the structure of MxM BS-RNase productive complexes than to the sulfate-bound form. These results reveal that MxM BS-RNase presents a remarkable flexibility, despite the structural constraints of the interchain disulfide bridges and the swapping of the N-terminal helices. These findings have important implications to the ligand binding mechanism of MxM BS-RNase. Indeed, a population shift rather than a substrate-induced conformational transition may occur in the MxM BS-RNase ligand binding process.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15048772}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15048772 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15048772}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Ribonuclease]]
[[Category: Ribonuclease]]
[[Category: X-ray diffraction]]
[[Category: X-ray diffraction]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:05:58 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:07:09 2008''

Revision as of 18:07, 28 July 2008

Image:1r5c.png

Template:STRUCTURE 1r5c

X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA)

Template:ABSTRACT PUBMED 15048772

About this Structure

1R5C is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Population shift vs induced fit: the case of bovine seminal ribonuclease swapping dimer., Merlino A, Vitagliano L, Sica F, Zagari A, Mazzarella L, Biopolymers. 2004 Apr 15;73(6):689-95. PMID:15048772

Page seeded by OCA on Mon Jul 28 21:07:09 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r5c"
Personal tools