200d

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[[Image:200d.gif|left|200px]]
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{{Seed}}
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[[Image:200d.png|left|200px]]
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{{STRUCTURE_200d| PDB=200d | SCENE= }}
{{STRUCTURE_200d| PDB=200d | SCENE= }}
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'''STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE'''
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===STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE===
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==Overview==
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In most metazoans, the telomeric cytosine-rich strand repeating sequence is d(TAACCC). The crystal structure of this sequence was solved to 1.9-A resolution. Four strands associate via the cytosine-containing parts to form a four-stranded intercalated structure held together by C.C+ hydrogen bonds. The base-paired strands are parallel to each other, and the two duplexes are intercalated into each other in opposite orientations. One TAA end forms a highly stabilized loop with the 5' thymine Hoogsteen-base-paired to the third adenine. The 5' end of this loop is in close proximity to the 3' end of one of the other intercalated cytosine strands. Instead of being entirely in a DNA duplex, this structure suggests the possibility of an alternative conformation for the cytosine-rich telomere strands.
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The line below this paragraph, {{ABSTRACT_PUBMED_7731999}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7731999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7731999}}
==About this Structure==
==About this Structure==
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[[Category: Tetraplex]]
[[Category: Tetraplex]]
[[Category: U-dna]]
[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:17:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:08:15 2008''

Revision as of 18:08, 28 July 2008

Image:200d.png

Template:STRUCTURE 200d

STABLE LOOP IN THE CRYSTAL STRUCTURE OF THE INTERCALATED FOUR-STRANDED CYTOSINE-RICH METAZOAN TELOMERE

Template:ABSTRACT PUBMED 7731999

About this Structure

Full crystallographic information is available from OCA.

Reference

Stable loop in the crystal structure of the intercalated four-stranded cytosine-rich metazoan telomere., Kang C, Berger I, Lockshin C, Ratliff R, Moyzis R, Rich A, Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3874-8. PMID:7731999

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