1ny4

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Revision as of 20:31, 20 November 2007

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Solution structure of the 30S ribosomal protein S28E from Pyrococcus horikoshii. Northeast Structural Genomics Consortium target JR19.

Overview

We report NMR assignments and solution structure of the 71-residue 30S, ribosomal protein S28E from the archaean Pyrococcus horikoshii, target, JR19 of the Northeast Structural Genomics Consortium. The structure, determined rapidly with the aid of automated backbone resonance assignment, (AutoAssign) and automated structure determination (AutoStructure), software, is characterized by a four-stranded beta-sheet with a classic, Greek-key topology and an oligonucleotide/oligosaccharide beta-barrel (OB), fold. The electrostatic surface of S28E exhibits positive and negative, patches on opposite sides, the former constituting a putative binding site, for RNA. The 13 C-terminal residues of the protein contain a consensus, sequence motif constituting the signature of the S28E protein family., Surprisingly, this C-terminal segment is unstructured in solution.

About this Structure

1NY4 is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Solution NMR structure of the 30S ribosomal protein S28E from Pyrococcus horikoshii., Aramini JM, Huang YJ, Cort JR, Goldsmith-Fischman S, Xiao R, Shih LY, Ho CK, Liu J, Rost B, Honig B, Kennedy MA, Acton TB, Montelione GT, Protein Sci. 2003 Dec;12(12):2823-30. PMID:14627742

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