2dwv

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{{STRUCTURE_2dwv| PDB=2dwv | SCENE= }}
{{STRUCTURE_2dwv| PDB=2dwv | SCENE= }}
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'''Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)'''
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===Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)===
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==Overview==
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The WW domain is known as one of the smallest protein modules with a triple-stranded beta-sheet fold. Here, we present the solution structure of the second WW domain from the mouse salvador homolog 1 protein. This WW domain forms a homodimer with a beta-clam-like motif, as evidenced by size exclusion chromatography, analytical ultracentrifugation and NMR spectroscopy. While typical WW domains are believed to function as monomeric modules that recognize proline-rich sequences, by using conserved aromatic and hydrophobic residues that are solvent-exposed on the surface of the beta-sheet, this WW domain buries these residues in the dimer interface.
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(as it appears on PubMed at http://www.pubmed.gov), where 17239860 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17239860}}
==About this Structure==
==About this Structure==
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2DWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWV OCA].
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2DWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DWV OCA].
==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Ww domain]]
[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:32:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:09:04 2008''

Revision as of 18:09, 28 July 2008

Image:2dwv.png

Template:STRUCTURE 2dwv

Solution structure of the second WW domain from mouse salvador homolog 1 protein (mWW45)

Template:ABSTRACT PUBMED 17239860

About this Structure

2DWV is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of an atypical WW domain in a novel beta-clam-like dimeric form., Ohnishi S, Guntert P, Koshiba S, Tomizawa T, Akasaka R, Tochio N, Sato M, Inoue M, Harada T, Watanabe S, Tanaka A, Shirouzu M, Kigawa T, Yokoyama S, FEBS Lett. 2007 Feb 6;581(3):462-8. Epub 2007 Jan 16. PMID:17239860

Page seeded by OCA on Mon Jul 28 21:09:04 2008

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