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1pto

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{{STRUCTURE_1pto| PDB=1pto | SCENE= }}
{{STRUCTURE_1pto| PDB=1pto | SCENE= }}
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'''THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING'''
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===THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING===
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==Overview==
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Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.
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(as it appears on PubMed at http://www.pubmed.gov), where 7634099 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7634099}}
==About this Structure==
==About this Structure==
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[[Category: Stein, P E.]]
[[Category: Stein, P E.]]
[[Category: Toxin]]
[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:12:08 2008''

Revision as of 18:12, 28 July 2008

Image:1pto.png

Template:STRUCTURE 1pto

THE STRUCTURE OF A PERTUSSIS TOXIN-SUGAR COMPLEX AS A MODEL FOR RECEPTOR BINDING

Template:ABSTRACT PUBMED 7634099

About this Structure

1PTO is a Protein complex structure of sequences from Bordetella pertussis. Full crystallographic information is available from OCA.

Reference

Structure of a pertussis toxin-sugar complex as a model for receptor binding., Stein PE, Boodhoo A, Armstrong GD, Heerze LD, Cockle SA, Klein MH, Read RJ, Nat Struct Biol. 1994 Sep;1(9):591-6. PMID:7634099

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