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2elg

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{{STRUCTURE_2elg| PDB=2elg | SCENE= }}
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'''The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 degree celsius'''
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===The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 degree celsius===
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==Overview==
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Several crystal structure analyses of complexes of synthetic polyamine compounds, including N(1)-(2-(2-aminoethylamino))ethyl)ethane-1,2-diamine PA(222) and N(1)-(2-(2-(2-aminoethylamino)ethylamino)ethyl)ethane-1,2-diamine PA(2222), and left-handed Z-DNA d(CGCGCG)(2) have been reported. However, until now, there have been no examples of naturally occurring polyamines bound to the minor groove of the left-handed Z-DNA of d(CGCGCG)(2) molecule. We have found that spermidine, a natural polyamine, is connected to the minor groove of left-handed Z-DNA of d(CGCGCG)(2) molecule in a crystalline complex grown at 10 degrees C. The electron density of the DNA molecule was clear enough to determine that the spermidine was connected in the minor groove of two symmetry related molecules of left-handed Z-DNA d(CGCGCG)(2). This is the first example that a spermidine molecule can form a bridge conformation between two symmetry related molecules of left-handed Z-DNA d(CGCGCG)(2) in the minor groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 17467661 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17467661}}
==About this Structure==
==About this Structure==
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[[Category: Spermidine]]
[[Category: Spermidine]]
[[Category: X-ray crystallography]]
[[Category: X-ray crystallography]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:15:24 2008''

Revision as of 18:15, 28 July 2008

Image:2elg.png

Template:STRUCTURE 2elg

The rare crystallographic structure of d(CGCGCG)2: The natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)2 at 10 degree celsius

Template:ABSTRACT PUBMED 17467661

About this Structure

2ELG is a Single protein structure. Full crystallographic information is available from OCA.

Reference

The rare crystallographic structure of d(CGCGCG)(2): the natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)(2) at 10 degrees C., Ohishi H, Tozuka Y, Da-Yang Z, Ishida T, Nakatani K, Biochem Biophys Res Commun. 2007 Jun 22;358(1):24-8. Epub 2007 Apr 17. PMID:17467661

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