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1ymm

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[[Image:1ymm.gif|left|200px]]
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{{Seed}}
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[[Image:1ymm.png|left|200px]]
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{{STRUCTURE_1ymm| PDB=1ymm | SCENE= }}
{{STRUCTURE_1ymm| PDB=1ymm | SCENE= }}
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'''TCR/HLA-DR2b/MBP-peptide complex'''
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===TCR/HLA-DR2b/MBP-peptide complex===
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==Overview==
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Autoimmune diseases are caused by self-reactive lymphocytes that have escaped deletion. Here we have determined the structure of the trimolecular complex for a T cell receptor (TCR) from a patient with multiple sclerosis that causes autoimmunity in transgenic mice. The structure showed a TCR topology notably different from that of antimicrobial TCRs. Rather than being centered on the peptide-major histocompatibility complex, this TCR contacted only the N-terminal peptide segment and made asymmetrical interactions with the major histocompatibility complex helices. The interaction was dominated by the hypervariable complementarity-determining region 3 loops, indicating that unconventional topologies are possible because of the unique complementarity-determining region 3 sequences created during rearrangement. This topology reduces the interaction surface with peptide and alters the geometry for CD4 association. We propose that unusual TCR-binding properties can permit autoreactive T cells to escape deletion.
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The line below this paragraph, {{ABSTRACT_PUBMED_15821740}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15821740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15821740}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: T cell repertoire]]
[[Category: T cell repertoire]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 16:30:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:15:44 2008''

Revision as of 18:15, 28 July 2008

Image:1ymm.png

Template:STRUCTURE 1ymm

TCR/HLA-DR2b/MBP-peptide complex

Template:ABSTRACT PUBMED 15821740

About this Structure

1YMM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor., Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW, Nat Immunol. 2005 May;6(5):490-6. Epub 2005 Apr 10. PMID:15821740

Page seeded by OCA on Mon Jul 28 21:15:44 2008

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