2auj

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{{STRUCTURE_2auj| PDB=2auj | SCENE= }}
{{STRUCTURE_2auj| PDB=2auj | SCENE= }}
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'''Structure of Thermus aquaticus RNA polymerase beta'-subunit insert'''
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===Structure of Thermus aquaticus RNA polymerase beta'-subunit insert===
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==Overview==
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The large beta and beta' subunits of the bacterial core RNA polymerase (RNAP) are highly conserved throughout evolution. Nevertheless, large sequence insertions in beta and beta' characterize specific evolutionary lineages of bacteria. The Thermus aquaticus RNAP beta' subunit contains a 283 residue insert between conserved regions A and B that is found in only four bacterial species. The Escherichia coli RNAP beta' subunit contains a 188 residue insert in the middle of conserved region G that is found in a wide range of bacterial species. Here, we present structural studies of these two beta' insertions. We show that the inserts comprise repeats of a previously characterized fold, the sandwich-barrel hybrid motif (as predicted from previous sequence analysis) and that the inserts serve significant roles in facilitating protein/protein and/or protein/nucleic acid interactions.
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{{ABSTRACT_PUBMED_16154587}}
==About this Structure==
==About this Structure==
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[[Category: Nikiforov, V.]]
[[Category: Nikiforov, V.]]
[[Category: Sandwich-barrel hybrid motif]]
[[Category: Sandwich-barrel hybrid motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:17:44 2008''

Revision as of 18:17, 28 July 2008

Image:2auj.png

Template:STRUCTURE 2auj

Structure of Thermus aquaticus RNA polymerase beta'-subunit insert

Template:ABSTRACT PUBMED 16154587

About this Structure

2AUJ is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Structure and function of lineage-specific sequence insertions in the bacterial RNA polymerase beta' subunit., Chlenov M, Masuda S, Murakami KS, Nikiforov V, Darst SA, Mustaev A, J Mol Biol. 2005 Oct 14;353(1):138-54. PMID:16154587

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