2eh7

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{{STRUCTURE_2eh7| PDB=2eh7 | SCENE= }}
{{STRUCTURE_2eh7| PDB=2eh7 | SCENE= }}
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'''Crystal structure of humanized KR127 FAB'''
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===Crystal structure of humanized KR127 FAB===
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==Overview==
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The humanized monoclonal antibody HzKR127 recognizes the preS1 domain of the human hepatitis B virus surface proteins with a broadly neutralizing activity in vivo. We present the crystal structures of HzKR127 Fab and its complex with a major epitope peptide. In the complex structure, the bound peptide forms a type IV beta-turn followed by 3(10) helical turn, the looped-out conformation of which provides a structural basis for broad neutralization. Upon peptide binding, the antibody undergoes a dramatic complementarity determining region H3 lid opening. To understand the structural implication of the virus neutralization, we carried out comprehensive alanine-scanning mutagenesis of all complementarity determining region residues in HzKR127 Fab. The functional mapping of the antigen-combining site demonstrates the specific roles of major binding determinants in antigen binding, contributing to the rational design for maximal humanization and affinity maturation of the antibody.
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{{ABSTRACT_PUBMED_17517649}}
==About this Structure==
==About this Structure==
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[[Category: Neutralization]]
[[Category: Neutralization]]
[[Category: Pres1]]
[[Category: Pres1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:18:55 2008''

Revision as of 18:18, 28 July 2008

Image:2eh7.png

Template:STRUCTURE 2eh7

Crystal structure of humanized KR127 FAB

Template:ABSTRACT PUBMED 17517649

About this Structure

2EH7 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism., Chi SW, Maeng CY, Kim SJ, Oh MS, Ryu CJ, Kim SJ, Han KH, Hong HJ, Ryu SE, Proc Natl Acad Sci U S A. 2007 May 29;104(22):9230-5. Epub 2007 May 17. PMID:17517649

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