1pgr

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[[Image:1pgr.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1pgr| PDB=1pgr | SCENE= }}
{{STRUCTURE_1pgr| PDB=1pgr | SCENE= }}
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'''2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR'''
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===2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR===
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==Overview==
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Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
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The line below this paragraph, {{ABSTRACT_PUBMED_10537111}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10537111 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10537111}}
==About this Structure==
==About this Structure==
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[[Category: Hematopoietic receptor]]
[[Category: Hematopoietic receptor]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:04:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:19:06 2008''

Revision as of 18:19, 28 July 2008

Image:1pgr.png

Template:STRUCTURE 1pgr

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

Template:ABSTRACT PUBMED 10537111

About this Structure

1PGR is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111

Page seeded by OCA on Mon Jul 28 21:19:06 2008

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