1rq7

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{{STRUCTURE_1rq7| PDB=1rq7 | SCENE= }}
{{STRUCTURE_1rq7| PDB=1rq7 | SCENE= }}
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'''MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP'''
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===MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP===
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==Overview==
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We report three crystal structures of the Mycobacterium tuberculosis cell division protein FtsZ, as the citrate, GDP, and GTPgammaS complexes, determined at 1.89, 2.60, and 2.08A resolution. MtbFtsZ crystallized as a tight, laterally oriented dimer distinct from the longitudinal polymer observed for alphabeta-tubulin. Mutational data on Escherichia coli FtsZ suggest that this dimer interface is important for proper protofilament and "Z-ring" assembly and function. An alpha-to-beta secondary structure conformational switch at the dimer interface is spatially analogous to, and has many of the hallmarks of, the Switch I conformational changes exhibited by G-proteins upon activation. The presence of a gamma-phosphate in the FtsZ active site modulates the conformation of the "tubulin" loop T3 (spatially analogous to the G-protein Switch II); T3 switching upon gamma-phosphate ligation is directly coupled to the alpha-to-beta switch by steric overlap. The dual conformational switches observed here for the first time in an FtsZ link GTP binding and hydrolysis to FtsZ (and tubulin) lateral assembly and Z-ring contraction, and they are suggestive of an underappreciated functional analogy between FtsZ, tubulin and G-proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 15342249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15342249}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches., Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW, J Mol Biol. 2004 Sep 17;342(3):953-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15342249 15342249]
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches., Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW, J Mol Biol. 2004 Sep 17;342(3):953-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15342249 15342249]
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Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ., Leung AK, White EL, Ross LJ, Borhani DW, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1634-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11092931 11092931]
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Slow polymerization of Mycobacterium tuberculosis FtsZ., White EL, Ross LJ, Reynolds RC, Seitz LE, Moore GD, Borhani DW, J Bacteriol. 2000 Jul;182(14):4028-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10869082 10869082]
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2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ., White EL, Suling WJ, Ross LJ, Seitz LE, Reynolds RC, J Antimicrob Chemother. 2002 Jul;50(1):111-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12096015 12096015]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Gtpase]]
[[Category: Gtpase]]
[[Category: Tubulin]]
[[Category: Tubulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:46:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:21:40 2008''

Revision as of 18:21, 28 July 2008

Image:1rq7.png

Template:STRUCTURE 1rq7

MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP

Template:ABSTRACT PUBMED 15342249

About this Structure

1RQ7 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches., Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW, J Mol Biol. 2004 Sep 17;342(3):953-70. PMID:15342249

Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ., Leung AK, White EL, Ross LJ, Borhani DW, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1634-7. PMID:11092931

Slow polymerization of Mycobacterium tuberculosis FtsZ., White EL, Ross LJ, Reynolds RC, Seitz LE, Moore GD, Borhani DW, J Bacteriol. 2000 Jul;182(14):4028-34. PMID:10869082

2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ., White EL, Suling WJ, Ross LJ, Seitz LE, Reynolds RC, J Antimicrob Chemother. 2002 Jul;50(1):111-4. PMID:12096015

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