1nz8

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Revision as of 20:33, 20 November 2007

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Solution Structure of the N-utilisation substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus

Overview

NusG is an essential bacterial protein modulator of transcriptional, elongation and termination events, and interacts directly with RNA, polymerase and Rho protein. Found also in Archaea, NusG shows stretches of, sequence similarity to the eukaryotic transcription elongation factor, Spt5. Herein, the three-dimensional solution structure of the bacterial, NusG from Thermus thermophilus, which shows 43% amino acid sequence, similarity to the Escherichia coli NusG, is described, and a survey of, NusG and Spt5 amino acid sequences is presented. Although there is a clear, evolutionary and functional relationship between these proteins, it is, evident from the structural, sequence, and biochemical data that their, binding specificities to both nucleic acids and other proteins differ.

About this Structure

1NZ8 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:15162485

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