2jp1

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{{STRUCTURE_2jp1| PDB=2jp1 | SCENE= }}
{{STRUCTURE_2jp1| PDB=2jp1 | SCENE= }}
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'''Solution structure of the alternative conformation of XCL1/Lymphotactin'''
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===Solution structure of the alternative conformation of XCL1/Lymphotactin===
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==Overview==
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Proteins often have multiple functional states, which might not always be accommodated by a single fold. Lymphotactin (Ltn) adopts two distinct structures in equilibrium, one corresponding to the canonical chemokine fold consisting of a monomeric three-stranded beta-sheet and carboxyl-terminal helix. The second Ltn structure solved by NMR reveals a dimeric all-beta-sheet arrangement with no similarity to other known proteins. In physiological solution conditions, both structures are significantly populated and interconvert rapidly. Interconversion replaces long-range interactions that stabilize the chemokine fold with an entirely new set of tertiary and quaternary contacts. The chemokine-like Ltn conformation is a functional XCR1 agonist, but fails to bind heparin. In contrast, the alternative structure binds glycosaminoglycans with high affinity but fails to activate XCR1. Because each structural species displays only one of the two functional properties essential for activity in vivo, the conformational equilibrium is likely to be essential for the biological activity of lymphotactin. These results demonstrate that the functional repertoire and regulation of a single naturally occurring amino acid sequence can be expanded by access to a set of highly dissimilar native-state structures.
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(as it appears on PubMed at http://www.pubmed.gov), where 18364395 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18364395}}
==About this Structure==
==About this Structure==
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2JP1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP1 OCA].
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2JP1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JP1 OCA].
==Reference==
==Reference==
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[[Category: Structural rearrangement]]
[[Category: Structural rearrangement]]
[[Category: Xcl1]]
[[Category: Xcl1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 30 13:28:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:26:45 2008''

Revision as of 18:26, 28 July 2008

Image:2jp1.png

Template:STRUCTURE 2jp1

Solution structure of the alternative conformation of XCL1/Lymphotactin

Template:ABSTRACT PUBMED 18364395

About this Structure

2JP1 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Interconversion between two unrelated protein folds in the lymphotactin native state., Tuinstra RL, Peterson FC, Kutlesa S, Elgin ES, Kron MA, Volkman BF, Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5057-62. Epub 2008 Mar 25. PMID:18364395

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