1o0k

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{{STRUCTURE_1o0k| PDB=1o0k | SCENE= }}
{{STRUCTURE_1o0k| PDB=1o0k | SCENE= }}
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'''Structure of the First Parallel DNA Quadruplex-drug Complex'''
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===Structure of the First Parallel DNA Quadruplex-drug Complex===
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==Overview==
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The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
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The line below this paragraph, {{ABSTRACT_PUBMED_12670225}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12670225 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12670225}}
==About this Structure==
==About this Structure==
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[[Category: G-4 quadruplex drug complex]]
[[Category: G-4 quadruplex drug complex]]
[[Category: Parallel quadruplex]]
[[Category: Parallel quadruplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:12:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:28:01 2008''

Revision as of 18:28, 28 July 2008

Image:1o0k.png


PDB ID 1o0k

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1o0k, resolution 1.17Å ()
Ligands: ,
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Structure of the First Parallel DNA Quadruplex-drug Complex

Template:ABSTRACT PUBMED 12670225

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225

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