1r0r

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{{STRUCTURE_1r0r| PDB=1r0r | SCENE= }}
{{STRUCTURE_1r0r| PDB=1r0r | SCENE= }}
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'''1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg'''
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===1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg===
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==Overview==
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Proteins with flexible binding surfaces can interact with numerous binding partners. However, this promiscuity is more difficult to understand in "rigid-body" proteins, whose binding results in little, or no, change in the position of backbone atoms. The binding of Kazal inhibitors to serine proteases is considered a classic case of rigid-body binding, although they bind to a wide range of proteases. We have studied the thermodynamics of binding of the Kazal serine protease inhibitor, turkey ovomucoid third domain (OMTKY3), to the serine protease subtilisin Carlsberg using isothermal titration calorimetry and have determined the crystal structure of the complex at very high resolution (1.1A). Comparison of the binding energetics and structure to other OMTKY3 interactions demonstrates that small changes in the position of side-chains can make significant contributions to the binding thermodynamics, including the enthalpy of binding. These effects emphasize that small, "rigid-body" proteins are still dynamic structures, and these dynamics make contributions to both the enthalpy and entropy of binding interactions.
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(as it appears on PubMed at http://www.pubmed.gov), where 12888355 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12888355}}
==About this Structure==
==About this Structure==
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[[Category: Protein inhibitor]]
[[Category: Protein inhibitor]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:55:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:29:03 2008''

Revision as of 18:29, 28 July 2008

Image:1r0r.png

Template:STRUCTURE 1r0r

1.1 Angstrom Resolution Structure of the Complex Between the Protein Inhibitor, OMTKY3, and the Serine Protease, Subtilisin Carlsberg

Template:ABSTRACT PUBMED 12888355

About this Structure

1R0R is a Protein complex structure of sequences from Bacillus licheniformis and Meleagris gallopavo. Full crystallographic information is available from OCA.

Reference

Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases., Horn JR, Ramaswamy S, Murphy KP, J Mol Biol. 2003 Aug 8;331(2):497-508. PMID:12888355

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