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3c2h

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{{STRUCTURE_3c2h| PDB=3c2h | SCENE= }}
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'''Crystal Structure of SYS-1 at 2.6A resolution'''
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===Crystal Structure of SYS-1 at 2.6A resolution===
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==Overview==
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C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a complex with POP-1, the C. elegans TCF homolog. The two structures possess signature features of canonical beta-catenin and the beta-catenin/TCF complex that could not be predicted by sequence. Most importantly, SYS-1 bears 12 armadillo repeats and the SYS-1/POP-1 interface is anchored by a conserved salt-bridge, the "charged button." We also modeled structures for three other C. elegans beta-catenins to predict the molecular basis of their distinct binding properties. Finally, we generated a phylogenetic tree, using the region of highest structural similarity between SYS-1 and beta-catenin, and found that SYS-1 clusters robustly within the beta-catenin clade. We conclude that the SYS-1 protein belongs to the beta-catenin family and suggest that additional divergent beta-catenins await discovery.
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==About this Structure==
==About this Structure==
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[[Category: Sys-1]]
[[Category: Sys-1]]
[[Category: Wnt]]
[[Category: Wnt]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:31:36 2008''

Revision as of 18:31, 28 July 2008

Image:3c2h.png

Template:STRUCTURE 3c2h

Crystal Structure of SYS-1 at 2.6A resolution

Template:ABSTRACT PUBMED 18477457

About this Structure

3C2H is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The C. elegans SYS-1 protein is a bona fide beta-catenin., Liu J, Phillips BT, Amaya MF, Kimble J, Xu W, Dev Cell. 2008 May;14(5):751-61. PMID:18477457

Page seeded by OCA on Mon Jul 28 21:31:36 2008

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