1wd9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1wd9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1wd9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1wd9| PDB=1wd9 | SCENE= }}
{{STRUCTURE_1wd9| PDB=1wd9 | SCENE= }}
-
'''Calcium bound form of human peptidylarginine deiminase type4 (PAD4)'''
+
===Calcium bound form of human peptidylarginine deiminase type4 (PAD4)===
-
==Overview==
+
<!--
-
Peptidylarginine deiminase 4 (PAD4) is a Ca(2+)-dependent enzyme that catalyzes the conversion of protein arginine residues to citrulline. Its gene is a susceptibility locus for rheumatoid arthritis. Here we present the crystal structure of Ca(2+)-free wild-type PAD4, which shows that the polypeptide chain adopts an elongated fold in which the N-terminal domain forms two immunoglobulin-like subdomains, and the C-terminal domain forms an alpha/beta propeller structure. Five Ca(2+)-binding sites, none of which adopt an EF-hand motif, were identified in the structure of a Ca(2+)-bound inactive mutant with and without bound substrate. These structural data indicate that Ca(2+) binding induces conformational changes that generate the active site cleft. Our findings identify a novel mechanism for enzyme activation by Ca(2+) ions, and are important for understanding the mechanism of protein citrullination and for developing PAD-inhibiting drugs for the treatment of rheumatoid arthritis.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15247907}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15247907 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15247907}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Yamada, M.]]
[[Category: Yamada, M.]]
[[Category: Post-translational enzyme]]
[[Category: Post-translational enzyme]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:29:53 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:32:18 2008''

Revision as of 18:32, 28 July 2008

Image:1wd9.png

Template:STRUCTURE 1wd9

Calcium bound form of human peptidylarginine deiminase type4 (PAD4)

Template:ABSTRACT PUBMED 15247907

About this Structure

1WD9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for Ca(2+)-induced activation of human PAD4., Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M, Nat Struct Mol Biol. 2004 Aug;11(8):777-83. Epub 2004 Jul 11. PMID:15247907

Page seeded by OCA on Mon Jul 28 21:32:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wd9"
Personal tools