2gum

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{{STRUCTURE_2gum| PDB=2gum | SCENE= }}
{{STRUCTURE_2gum| PDB=2gum | SCENE= }}
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'''Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I'''
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===Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I===
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==Overview==
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Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
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(as it appears on PubMed at http://www.pubmed.gov), where 16840698 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16840698}}
==About this Structure==
==About this Structure==
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[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Virus]]
[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:33:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:34:11 2008''

Revision as of 18:34, 28 July 2008

Image:2gum.png

Template:STRUCTURE 2gum

Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I

Template:ABSTRACT PUBMED 16840698

About this Structure

2GUM is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of glycoprotein B from herpes simplex virus 1., Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC, Science. 2006 Jul 14;313(5784):217-20. PMID:16840698

Page seeded by OCA on Mon Jul 28 21:34:11 2008

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