1qgh

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[[Image:1qgh.gif|left|200px]]
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{{STRUCTURE_1qgh| PDB=1qgh | SCENE= }}
{{STRUCTURE_1qgh| PDB=1qgh | SCENE= }}
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'''THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.'''
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===THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.===
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==Overview==
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Ferritin is characterized by a highly conserved architecture that comprises 24 subunits assembled into a spherical cage with 432 symmetry. The only known exception is the dodecameric ferritin from Listeria innocua. The structure of Listeria ferritin has been determined to a resolution of 2.35 A by molecular replacement, using as a search model the structure of Dps from Escherichia coli. The Listeria 12-mer is endowed with 23 symmetry and displays the functionally relevant structural features of the ferritin 24-mer, namely the negatively charged channels along the three-fold symmetry axes that serve for iron entry into the cavity and a negatively charged internal cavity for iron deposition. The electron density map shows 12 iron ions on the inner surface of the hollow core, at the interface between monomers related by two-fold axes. Analysis of the nature and stereochemistry of the iron-binding ligands reveals strong similarities with known ferroxidase sites. The L. innocua ferritin site, however, is the first described so far that has ligands belonging to two different subunits and is not contained within a four-helix bundle.
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The line below this paragraph, {{ABSTRACT_PUBMED_10625425}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10625425 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10625425}}
==About this Structure==
==About this Structure==
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[[Category: Tsernoglou, D.]]
[[Category: Tsernoglou, D.]]
[[Category: Ferritin]]
[[Category: Ferritin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:14:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:34:46 2008''

Revision as of 18:34, 28 July 2008

Image:1qgh.png

Template:STRUCTURE 1qgh

THE X-RAY STRUCTURE OF THE UNUSUAL DODECAMERIC FERRITIN FROM LISTERIA INNOCUA, REVEALS A NOVEL INTERSUBUNIT IRON BINDING SITE.

Template:ABSTRACT PUBMED 10625425

About this Structure

1QGH is a Single protein structure of sequence from Listeria innocua. Full crystallographic information is available from OCA.

Reference

The dodecameric ferritin from Listeria innocua contains a novel intersubunit iron-binding site., Ilari A, Stefanini S, Chiancone E, Tsernoglou D, Nat Struct Biol. 2000 Jan;7(1):38-43. PMID:10625425

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