2cy7

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[[Image:2cy7.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2cy7| PDB=2cy7 | SCENE= }}
{{STRUCTURE_2cy7| PDB=2cy7 | SCENE= }}
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'''The crystal structure of human Atg4B'''
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===The crystal structure of human Atg4B===
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==Overview==
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Reversible modification of Atg8 with phosphatidylethanolamine is crucial for autophagy, the bulk degradation system conserved in eukaryotic cells. Atg4 is a novel cysteine protease that processes and deconjugates Atg8. Herein, we report the crystal structure of human Atg4B (HsAtg4B) at 1.9-A resolution. Despite no obvious sequence homology with known proteases, the structure of HsAtg4B shows a classical papain-like fold. In addition to the papain fold region, HsAtg4B has a small alpha/beta-fold domain. This domain is thought to be the binding site for Atg8 homologs. The active site cleft of HsAtg4B is masked by a loop (residues 259-262), implying a conformational change upon substrate binding. The structure and in vitro mutational analyses provide the basis for the specificity and catalysis of HsAtg4B. This will enable the design of Atg4-specific inhibitors that block autophagy.
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The line below this paragraph, {{ABSTRACT_PUBMED_16183633}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16183633 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16183633}}
==About this Structure==
==About this Structure==
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[[Category: Autophagy]]
[[Category: Autophagy]]
[[Category: Papain-like fold]]
[[Category: Papain-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:20:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:34:57 2008''

Revision as of 18:35, 28 July 2008

Image:2cy7.png

Template:STRUCTURE 2cy7

The crystal structure of human Atg4B

Template:ABSTRACT PUBMED 16183633

About this Structure

2CY7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the specificity and catalysis of human Atg4B responsible for mammalian autophagy., Sugawara K, Suzuki NN, Fujioka Y, Mizushima N, Ohsumi Y, Inagaki F, J Biol Chem. 2005 Dec 2;280(48):40058-65. Epub 2005 Sep 23. PMID:16183633

Page seeded by OCA on Mon Jul 28 21:34:57 2008

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