1wac

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{{STRUCTURE_1wac| PDB=1wac | SCENE= }}
{{STRUCTURE_1wac| PDB=1wac | SCENE= }}
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'''BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE'''
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===BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE===
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==Overview==
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The RNA-dependent RNA polymerase of the double-stranded RNA bacteriophage phi6 is capable of primer-independent initiation, as are many RNA polymerases. The structure of this polymerase revealed an initiation platform, composed of a loop in the C-terminal domain (QYKW, aa 629-632), that was essential for de novo initiation. A similar element has been identified in hepatitis C virus RNA-dependent RNA polymerase. Biochemical studies have addressed the role of this platform, revealing that a mutant version can utilize a back-priming initiation mechanism, where the 3' terminus of the template adopts a hairpin-like conformation. Here, the mechanism of back-primed initiation is studied further by biochemical and structural methods.
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(as it appears on PubMed at http://www.pubmed.gov), where 15659773 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15659773}}
==About this Structure==
==About this Structure==
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[[Category: Phi6 rna-dependent rna polymerase]]
[[Category: Phi6 rna-dependent rna polymerase]]
[[Category: Transcription]]
[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:22:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:37:14 2008''

Revision as of 18:37, 28 July 2008

Image:1wac.png

Template:STRUCTURE 1wac

BACK-PRIMING MODE OF PHI6 RNA-DEPENDENT RNA POLYMERASE

Template:ABSTRACT PUBMED 15659773

About this Structure

1WAC is a Single protein structure of sequence from Pseudomonas phage phi6. Full crystallographic information is available from OCA.

Reference

Back-priming mode of phi6 RNA-dependent RNA polymerase., Laurila MR, Salgado PS, Stuart DI, Grimes JM, Bamford DH, J Gen Virol. 2005 Feb;86(Pt 2):521-6. PMID:15659773

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