1rng

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[[Image:1rng.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1rng| PDB=1rng | SCENE= }}
{{STRUCTURE_1rng| PDB=1rng | SCENE= }}
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'''SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF'''
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===SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF===
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==Overview==
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The solution structure of a uniformly 13C/15N-labeled CUUG RNA hairpin loop has been determined by multidimensional heteronuclear magnetic resonance spectroscopy in combination with distance geometry and restrained molecular dynamics calculations. The structure of this CUUG tetraloop represents a novel RNA loop motif where the first and last loop nucleotides form a standard Watson-Crick C-G base pair and the second loop nucleotide interacts directly with the closing base pair of the stem by folding into the minor groove. This structure helps explain why the closing base pair is phylogenetically conserved and indicates a six-nucleotide G(CUNG)C motif for the CUUG RNA tetraloop. Implications for the function of this CUUG tetraloop in ribosomal RNA and in RNA tertiary interactions are discussed.
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The line below this paragraph, {{ABSTRACT_PUBMED_7578046}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7578046 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7578046}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RNG OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RNG OCA].
==Reference==
==Reference==
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:42:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:43:35 2008''

Revision as of 18:43, 28 July 2008

Image:1rng.png

Template:STRUCTURE 1rng

SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF

Template:ABSTRACT PUBMED 7578046

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif., Jucker FM, Pardi A, Biochemistry. 1995 Nov 7;34(44):14416-27. PMID:7578046

Page seeded by OCA on Mon Jul 28 21:43:35 2008

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