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1wxz

From Proteopedia

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[[Image:1wxz.gif|left|200px]]
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{{Seed}}
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[[Image:1wxz.png|left|200px]]
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{{STRUCTURE_1wxz| PDB=1wxz | SCENE= }}
{{STRUCTURE_1wxz| PDB=1wxz | SCENE= }}
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'''Crystal structure of adenosine deaminase ligated with a potent inhibitor'''
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===Crystal structure of adenosine deaminase ligated with a potent inhibitor===
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==Overview==
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From metabolic considerations and prediction of an inhibitor-induced conformational change, novel adenosine deaminase (ADA) inhibitors with improved activities and oral bioavailability have been developed on the basis of our originally designed non-nucleoside ADA inhibitors. They demonstrated in vivo efficacy in models of inflammation and lymphoma. Furthermore, X-ray crystal structure analysis has revealed a novel induced fit to ADA.
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The line below this paragraph, {{ABSTRACT_PUBMED_16033254}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16033254 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16033254}}
==About this Structure==
==About this Structure==
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[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Beta barel]]
[[Category: Beta barel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:17:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:43:39 2008''

Revision as of 18:43, 28 July 2008

Image:1wxz.png

Template:STRUCTURE 1wxz

Crystal structure of adenosine deaminase ligated with a potent inhibitor

Template:ABSTRACT PUBMED 16033254

About this Structure

1WXZ is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism., Terasaka T, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Inoue T, Tanaka K, Nakamura K, J Med Chem. 2005 Jul 28;48(15):4750-3. PMID:16033254

Page seeded by OCA on Mon Jul 28 21:43:39 2008

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