2jnb

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[[Image:2jnb.jpg|left|200px]]
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{{STRUCTURE_2jnb| PDB=2jnb | SCENE= }}
{{STRUCTURE_2jnb| PDB=2jnb | SCENE= }}
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'''Solution Structure of RNA-binding protein 15.5K'''
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===Solution Structure of RNA-binding protein 15.5K===
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==Overview==
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The kink-turn (K-turn) motif is recognized and bound by a family of proteins that act as nucleation factors for ribonucleoparticle assembly. The binding of various proteins to a conserved RNA structural motif known as the K-turn has been shown to be an important component of regulation in the ribosome, in the spliceosome, and in RNA modification. 15.5K is a prototypical example of a K-turn binding protein, which has been shown to bind the 5'-U4 stem-loop of the spliceosome and the box C/D motif. We describe the solution NMR structure of free 15.5K, as well as studies of conformational flexibility from 15N NMR relaxation and H/D exchange experiments. The protein appears well-structured aside from conformational fluctuation in alpha3. Flexibility in fast time scale motions and the observation of limited intermediate and slow motions further characterize the free protein and may suggest local contributions to recognition and binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 18044964 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18044964}}
==About this Structure==
==About this Structure==
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2JNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNB OCA].
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2JNB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JNB OCA].
==Reference==
==Reference==
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[[Category: Rna binding protein]]
[[Category: Rna binding protein]]
[[Category: Splicing]]
[[Category: Splicing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:03:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:51:48 2008''

Revision as of 18:51, 28 July 2008

Image:2jnb.png

Template:STRUCTURE 2jnb

Solution Structure of RNA-binding protein 15.5K

Template:ABSTRACT PUBMED 18044964

About this Structure

2JNB is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Functional implications for a prototypical K-turn binding protein from structural and dynamical studies of 15.5K., Soss SE, Flynn PF, Biochemistry. 2007 Dec 25;46(51):14979-86. Epub 2007 Nov 29. PMID:18044964

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