2ns1

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{{STRUCTURE_2ns1| PDB=2ns1 | SCENE= }}
{{STRUCTURE_2ns1| PDB=2ns1 | SCENE= }}
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'''Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK'''
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===Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK===
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==Overview==
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Ammonia conductance is highly regulated. A P(II) signal transduction protein, GlnK, is the final regulator of transmembrane ammonia conductance by the ammonia channel AmtB in Escherichia coli. The complex formed between AmtB and inhibitory GlnK at 1.96-A resolution shows that the trimeric channel is blocked directly by GlnK and how, in response to intracellular nitrogen status, the ability of GlnK to block the channel is regulated by uridylylation/deuridylylation at Y51. ATP and Mg(2+) augment the interaction of GlnK. The hydrolyzed product, adenosine 5'-diphosphate orients the surface of GlnK for AmtB blockade. 2-Oxoglutarate diminishes AmtB/GlnK association, and sites for 2-oxoglutarate are evaluated.
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(as it appears on PubMed at http://www.pubmed.gov), where 17190799 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17190799}}
==About this Structure==
==About this Structure==
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[[Category: Signal protein]]
[[Category: Signal protein]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:57:33 2008''

Revision as of 18:57, 28 July 2008

Image:2ns1.png

Template:STRUCTURE 2ns1

Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK

Template:ABSTRACT PUBMED 17190799

About this Structure

2NS1 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A., Gruswitz F, O'Connell J 3rd, Stroud RM, Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):42-7. Epub 2006 Dec 26. PMID:17190799

Page seeded by OCA on Mon Jul 28 21:57:33 2008

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