1z3s

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{{STRUCTURE_1z3s| PDB=1z3s | SCENE= }}
{{STRUCTURE_1z3s| PDB=1z3s | SCENE= }}
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'''Angiopoietin-2 Receptor Binding Domain'''
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===Angiopoietin-2 Receptor Binding Domain===
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==Overview==
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The angiopoietins comprise a small class of secreted glycoproteins that play crucial roles in the maturation and maintenance of the mammalian vascular and lymphatic systems. They exert their effects through a member of the tyrosine kinase receptor family, Tie2. Angiopoietin/Tie2 signaling is unique among tyrosine kinase receptor-ligand systems in that distinct angiopoietin ligands, although highly homologous, can function as agonists or antagonists in a context-dependent manner. In an effort to understand this molecular dichotomy, we have crystallized and determined the 2.4 A crystal structure of the Angiopoietin-2 (Ang2) receptor binding region. The structure reveals a fibrinogen fold with a unique C-terminal P domain. Conservation analysis and structure-based mutagenesis identify a groove on the Ang2 molecular surface that mediates receptor recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 15893672 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15893672}}
==About this Structure==
==About this Structure==
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[[Category: Angiogenesis]]
[[Category: Angiogenesis]]
[[Category: Tie2 binding]]
[[Category: Tie2 binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:08:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:00:42 2008''

Revision as of 19:00, 28 July 2008

Image:1z3s.png

Template:STRUCTURE 1z3s

Angiopoietin-2 Receptor Binding Domain

Template:ABSTRACT PUBMED 15893672

About this Structure

1Z3S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition., Barton WA, Tzvetkova D, Nikolov DB, Structure. 2005 May;13(5):825-32. PMID:15893672

Page seeded by OCA on Mon Jul 28 22:00:42 2008

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