2fif

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[[Image:2fif.gif|left|200px]]
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{{Seed}}
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[[Image:2fif.png|left|200px]]
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{{STRUCTURE_2fif| PDB=2fif | SCENE= }}
{{STRUCTURE_2fif| PDB=2fif | SCENE= }}
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'''Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin'''
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===Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin===
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==Overview==
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Rabex-5 is an exchange factor for Rab5, a master regulator of endosomal trafficking. Rabex-5 binds monoubiquitin, undergoes covalent ubiquitination and contains an intrinsic ubiquitin ligase activity, all of which require an N-terminal A20 zinc finger followed immediately by a helix. The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites. The first site is a new type of ubiquitin-binding domain, an inverted ubiquitin-interacting motif, which binds with approximately 29-microM affinity to the canonical Ile44 hydrophobic patch on ubiquitin. The second is a diaromatic patch on the A20 zinc finger, which binds with approximately 22-microM affinity to a polar region centered on Asp58 of ubiquitin. The A20 zinc-finger diaromatic patch mediates ubiquitin-ligase activity by directly recruiting a ubiquitin-loaded ubiquitin-conjugating enzyme.
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The line below this paragraph, {{ABSTRACT_PUBMED_16462746}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16462746 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16462746}}
==About this Structure==
==About this Structure==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:56:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:03:41 2008''

Revision as of 19:03, 28 July 2008

Image:2fif.png

Template:STRUCTURE 2fif

Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

Template:ABSTRACT PUBMED 16462746

About this Structure

2FIF is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5., Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Mar;13(3):264-71. Epub 2006 Feb 5. PMID:16462746

Page seeded by OCA on Mon Jul 28 22:03:41 2008

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