This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rp3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1rp3.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1rp3.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rp3| PDB=1rp3 | SCENE= }}
{{STRUCTURE_1rp3| PDB=1rp3 | SCENE= }}
-
'''Cocrystal structure of the flagellar sigma/anti-sigma complex, Sigma-28/FlgM'''
+
===Cocrystal structure of the flagellar sigma/anti-sigma complex, Sigma-28/FlgM===
-
==Overview==
+
<!--
-
The key regulators of bacterial transcription initiation are the sigma factors, which direct promoter recognition and melting but only after binding to the core RNA polymerase to form the holoenzyme. X-ray crystal structures of the flagellar sigma, sigma(28), in complex with its anti-sigma, FlgM, explain the inhibition mechanism of FlgM, including its ability to attack and destabilize the sigma(28)-holoenzyme. The sigma domains (sigma(2), sigma(3), and sigma(4)) pack together in a compact unit with extensive interdomain interfaces that bury the promoter binding determinants, including the -35 element recognition helix of sigma(4), which fits in an acidic groove on the surface of sigma(3). The structure illustrates the large rearrangements that sigma(28) must undergo to form the holoenzyme and provides insights into the regulation of sigma(28) promoter binding activity that may extend, at least in principle, to other sigmas.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15068809}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15068809 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15068809}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Sigma factor]]
[[Category: Sigma factor]]
[[Category: Transcription]]
[[Category: Transcription]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:44:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:07:20 2008''

Revision as of 19:07, 28 July 2008

Image:1rp3.png

Template:STRUCTURE 1rp3

Cocrystal structure of the flagellar sigma/anti-sigma complex, Sigma-28/FlgM

Template:ABSTRACT PUBMED 15068809

About this Structure

1RP3 is a Protein complex structure of sequences from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation., Sorenson MK, Ray SS, Darst SA, Mol Cell. 2004 Apr 9;14(1):127-38. PMID:15068809

Page seeded by OCA on Mon Jul 28 22:07:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rp3"
Personal tools