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2pav

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{{STRUCTURE_2pav| PDB=2pav | SCENE= }}
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'''Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP'''
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===Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP===
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==Overview==
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Cells sustain high rates of actin filament elongation by maintaining a large pool of actin monomers above the critical concentration for polymerization. Profilin-actin complexes constitute the largest fraction of polymerization-competent actin monomers. Filament elongation factors such as Ena/VASP and formin catalyze the transition of profilin-actin from the cellular pool onto the barbed end of growing filaments. The molecular bases of this process are poorly understood. Here we present structural and energetic evidence for two consecutive steps of the elongation mechanism: the recruitment of profilin-actin by the last poly-Pro segment of vasodilator-stimulated phosphoprotein (VASP) and the binding of profilin-actin simultaneously to this poly-Pro and to the G-actin-binding (GAB) domain of VASP. The actin monomer bound at the GAB domain is proposed to be in position to join the barbed end of the growing filament concurrently with the release of profilin.
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{{ABSTRACT_PUBMED_17914456}}
==About this Structure==
==About this Structure==
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[[Category: Ternary complex]]
[[Category: Ternary complex]]
[[Category: Vasp]]
[[Category: Vasp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:45:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:09:50 2008''

Revision as of 19:09, 28 July 2008

Image:2pav.png


PDB ID 2pav

Drag the structure with the mouse to rotate
2pav, resolution 1.80Å ()
Ligands: ,
Non-Standard Residues:
Gene: PFN1 (Homo sapiens)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Ternary complex of Profilin-Actin with the Last Poly-Pro of Human VASP

Template:ABSTRACT PUBMED 17914456

About this Structure

2PAV is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP., Ferron F, Rebowski G, Lee SH, Dominguez R, EMBO J. 2007 Oct 31;26(21):4597-606. Epub 2007 Oct 4. PMID:17914456

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