1p4u

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{{STRUCTURE_1p4u| PDB=1p4u | SCENE= }}
{{STRUCTURE_1p4u| PDB=1p4u | SCENE= }}
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'''CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE'''
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===CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE===
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==Overview==
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Adaptor proteins load transmembrane protein cargo into transport vesicles and serve as nexuses for the formation of large multiprotein complexes on the nascent vesicles. The gamma-adaptin ear (GAE) domains of the AP-1 adaptor protein complex and the GGA adaptor proteins recruit accessory proteins to these multiprotein complexes by binding to a hydrophobic motif. We determined the structure of the GAE domain of human GGA3 in complex with a peptide based on the DFGPLV sequence of the accessory protein Rabaptin-5 and refined it at a resolution of 2.2 A. The leucine and valine residues of the peptide are partly buried in two contiguous shallow, hydrophobic depressions. The anchoring phenylalanine is buried in a deep pocket formed by the aliphatic portions of two conserved arginine residues, along with an alanine and a proline, illustrating the unusual function of a cluster of basic residues in binding a hydrophobic motif.
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(as it appears on PubMed at http://www.pubmed.gov), where 12858162 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12858162}}
==About this Structure==
==About this Structure==
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[[Category: Miller, G J.]]
[[Category: Miller, G J.]]
[[Category: Protein transport]]
[[Category: Protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:41:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:13:19 2008''

Revision as of 19:13, 28 July 2008

Image:1p4u.png

Template:STRUCTURE 1p4u

CRYSTAL STRUCTURE OF GGA3 GAE DOMAIN IN COMPLEX WITH RABAPTIN-5 PEPTIDE

Template:ABSTRACT PUBMED 12858162

About this Structure

1P4U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Recognition of accessory protein motifs by the gamma-adaptin ear domain of GGA3., Miller GJ, Mattera R, Bonifacino JS, Hurley JH, Nat Struct Biol. 2003 Aug;10(8):599-606. PMID:12858162

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