1mwe

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[[Image:1mwe.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1mwe| PDB=1mwe | SCENE= }}
{{STRUCTURE_1mwe| PDB=1mwe | SCENE= }}
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'''THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE'''
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===THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE===
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==Overview==
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The x-ray structure of a complex of sialic acid (Neu5Ac) with neuraminidase N9 subtype from A/tern/Australia/G70C/75 influenza virus at 4 degrees C has revealed the location of a second Neu5Ac binding site on the surface of the enzyme. At 18 degrees C, only the enzyme active site contains bound Neu5Ac. Neu5Ac binds in the second site in the chair conformation in a similar way to which it binds to hemagglutinin. The residues that interact with Neu5Ac at this second site are mostly conserved in avian strains, but not in human and swine strains, indicating that it has some as-yet-unknown biological function in birds.
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(as it appears on PubMed at http://www.pubmed.gov), where 9342319 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9342319}}
==About this Structure==
==About this Structure==
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[[Category: Neuraminidase]]
[[Category: Neuraminidase]]
[[Category: Sialic acid binding]]
[[Category: Sialic acid binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:48:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:15:11 2008''

Revision as of 19:15, 28 July 2008

Image:1mwe.png

Template:STRUCTURE 1mwe

THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH SIALIC ACID AT 4 DEGREES C REVEALING A SECOND SIALIC ACID BINDING SITE

Template:ABSTRACT PUBMED 9342319

About this Structure

1MWE is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases., Varghese JN, Colman PM, van Donkelaar A, Blick TJ, Sahasrabudhe A, McKimm-Breschkin JL, Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11808-12. PMID:9342319

Page seeded by OCA on Mon Jul 28 22:15:11 2008

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