1sig

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{{STRUCTURE_1sig| PDB=1sig | SCENE= }}
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'''CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE'''
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===CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE===
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==Overview==
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The 2.6 A crystal structure of a fragment of the sigma 70 promoter specificity subunit of E. coli RNA polymerase is described. Residues involved in core RNA polymerase binding lie on one face of the structure. On the opposite face, aligned along one helix, are exposed residues that interact with the -10 consensus promoter element (the Pribnow box), including four aromatic residues involved in promoter melting. The structure suggests one way in which DNA interactions may be inhibited in the absence of RNA polymerase and provides a framework for the interpretation of a large number of genetic and biochemical analyses.
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(as it appears on PubMed at http://www.pubmed.gov), where 8858155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8858155}}
==About this Structure==
==About this Structure==
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[[Category: Rna polymerase sigma factor]]
[[Category: Rna polymerase sigma factor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:44:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:18:05 2008''

Revision as of 19:18, 28 July 2008

Image:1sig.png

Template:STRUCTURE 1sig

CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE

Template:ABSTRACT PUBMED 8858155

About this Structure

1SIG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase., Malhotra A, Severinova E, Darst SA, Cell. 1996 Oct 4;87(1):127-36. PMID:8858155

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