1q5b

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[[Image:1q5b.gif|left|200px]]
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{{Seed}}
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[[Image:1q5b.png|left|200px]]
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{{STRUCTURE_1q5b| PDB=1q5b | SCENE= }}
{{STRUCTURE_1q5b| PDB=1q5b | SCENE= }}
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'''lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography'''
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===lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography===
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==Overview==
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Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction.
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The line below this paragraph, {{ABSTRACT_PUBMED_14526082}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14526082 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14526082}}
==About this Structure==
==About this Structure==
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[[Category: Junction]]
[[Category: Junction]]
[[Category: Trans interaction]]
[[Category: Trans interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:52:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:25:59 2008''

Revision as of 19:26, 28 July 2008

Image:1q5b.png

Template:STRUCTURE 1q5b

lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography

Template:ABSTRACT PUBMED 14526082

About this Structure

Full crystallographic information is available from OCA.

Reference

Untangling desmosomal knots with electron tomography., He W, Cowin P, Stokes DL, Science. 2003 Oct 3;302(5642):109-13. PMID:14526082

Page seeded by OCA on Mon Jul 28 22:25:59 2008

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