1wzu

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[[Image:1wzu.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1wzu| PDB=1wzu | SCENE= }}
{{STRUCTURE_1wzu| PDB=1wzu | SCENE= }}
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'''Crystal structure of quinolinate synthase (nadA)'''
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===Crystal structure of quinolinate synthase (nadA)===
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==Overview==
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A gene encoding a quinolinate synthase has been identified in the hyperthermophilic archaeon Pyrococcus horikoshii via genome sequencing. The gene was overexpressed in Escherichia coli, and the crystal structure of the produced enzyme was determined to 2.0 A resolution in the presence of malate, a substrate analogue. The overall structure exhibits a unique triangular architecture composed of a 3-fold repeat of three-layer (alphabetaalpha) sandwich folding. Although some aspects of the fold homologous to the each domain have been observed previously, the overall structure of quinolinate synthase shows no similarity to any known protein structure. The three analogous domains are related to a pseudo-3-fold symmetry. The active site is located at the interface of the three domains and is centered on the pseudo-3-fold axis. The malate molecule is tightly held near the bottom of the active site cavity. The model of the catalytic state during the first condensation step of the quinolinate synthase reaction indicates that the elimination of inorganic phosphate from dihydroxyacetone phosphate may precede the condensation reaction.
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The line below this paragraph, {{ABSTRACT_PUBMED_15937336}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15937336 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15937336}}
==About this Structure==
==About this Structure==
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[[Category: Sakuraba, H.]]
[[Category: Sakuraba, H.]]
[[Category: Nad]]
[[Category: Nad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:21:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:30:40 2008''

Revision as of 19:30, 28 July 2008

Image:1wzu.png

Template:STRUCTURE 1wzu

Crystal structure of quinolinate synthase (nadA)

Template:ABSTRACT PUBMED 15937336

About this Structure

1WZU is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.

Reference

Crystal structure of the NAD biosynthetic enzyme quinolinate synthase., Sakuraba H, Tsuge H, Yoneda K, Katunuma N, Ohshima T, J Biol Chem. 2005 Jul 22;280(29):26645-8. Epub 2005 Jun 3. PMID:15937336

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