1ou8

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{{STRUCTURE_1ou8| PDB=1ou8 | SCENE= }}
{{STRUCTURE_1ou8| PDB=1ou8 | SCENE= }}
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'''structure of an AAA+ protease delivery protein in complex with a peptide degradation tag'''
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===structure of an AAA+ protease delivery protein in complex with a peptide degradation tag===
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==Overview==
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Substrate selection by AAA+ ATPases that function to unfold proteins or alter protein conformation is often regulated by delivery or adaptor proteins. SspB is a protein dimer that binds to the ssrA degradation tag and delivers proteins bearing this tag to ClpXP, an AAA+ protease, for degradation. Here, we describe the structure of the peptide binding domain of H. influenzae SspB in complex with an ssrA peptide at 1.6 A resolution. The ssrA peptides are bound in well-defined clefts located at the extreme ends of the SspB homodimer. SspB contacts residues within the N-terminal and central regions of the 11 residue ssrA tag but leaves the C-terminal residues exposed and positioned to dock with ClpX. This structure, taken together with biochemical analysis of SspB, suggests mechanisms by which proteins like SspB escort substrates to AAA+ ATPases and enhance the specificity and affinity of target recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 14536076 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14536076}}
==About this Structure==
==About this Structure==
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[[Category: Peptide-binding pocket]]
[[Category: Peptide-binding pocket]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:17:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:37:26 2008''

Revision as of 19:37, 28 July 2008

Image:1ou8.png

Template:STRUCTURE 1ou8

structure of an AAA+ protease delivery protein in complex with a peptide degradation tag

Template:ABSTRACT PUBMED 14536076

About this Structure

1OU8 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag., Levchenko I, Grant RA, Wah DA, Sauer RT, Baker TA, Mol Cell. 2003 Aug;12(2):365-72. PMID:14536076

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