1woq

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{{STRUCTURE_1woq| PDB=1woq | SCENE= }}
{{STRUCTURE_1woq| PDB=1woq | SCENE= }}
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'''Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution'''
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===Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution===
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==Overview==
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Inorganic polyphosphate (poly(P)) is a biological high energy compound presumed to be an ancient energy carrier preceding ATP. Several poly(P)-dependent kinases that use poly(P) as a phosphoryl donor are known to function in bacteria, but crystal structures of these kinases have not been solved. Here we present the crystal structure of bacterial poly(P)/ATP-glucomannokinase, belonging to Gram-positive bacterial glucokinase, complexed with 1 glucose molecule and 2 phosphate molecules at 1.8 A resolution, being the first among poly(P)-dependent kinases and bacterial glucokinases. The poly(P)/ATP-glucomannokinase structure enabled us to understand the structural relationship of bacterial glucokinase to eucaryotic hexokinase and ADP-glucokinase, which has remained a matter of debate. These comparisons also enabled us to propose putative binding sites for phosphoryl groups for ATP and especially for poly(P) and to obtain insights into the evolution of kinase, particularly from primordial poly(P)-specific to ubiquitous ATP-specific proteins.
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{{ABSTRACT_PUBMED_15377666}}
==About this Structure==
==About this Structure==
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[[Category: Glucomannokinase]]
[[Category: Glucomannokinase]]
[[Category: Polyphosphate]]
[[Category: Polyphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:57:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:50:44 2008''

Revision as of 19:50, 28 July 2008

Image:1woq.png

Template:STRUCTURE 1woq

Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution

Template:ABSTRACT PUBMED 15377666

About this Structure

1WOQ is a Single protein structure of sequence from Arthrobacter sp.. Full crystallographic information is available from OCA.

Reference

Crystal structure of bacterial inorganic polyphosphate/ATP-glucomannokinase. Insights into kinase evolution., Mukai T, Kawai S, Mori S, Mikami B, Murata K, J Biol Chem. 2004 Nov 26;279(48):50591-600. Epub 2004 Sep 17. PMID:15377666

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