2d1n

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{{STRUCTURE_2d1n| PDB=2d1n | SCENE= }}
{{STRUCTURE_2d1n| PDB=2d1n | SCENE= }}
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'''Collagenase-3 (MMP-13) complexed to a hydroxamic acid inhibitor'''
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===Collagenase-3 (MMP-13) complexed to a hydroxamic acid inhibitor===
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==Overview==
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Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453 have been solved at 2.01 and 2.37A resolutions, respectively. The results revealed that the binding modes for this inhibitor to MMP-3 and -13 were quite similar. However, subtle comparative differences were observed at the bottom of S1' pockets, which were occupied with the guanidinomethyl moiety of the inhibitor. A remarkable feature of the inhibitor was the deep penetration of its long aliphatic chain into the S1' pocket and exposure of the guanidinomethyl moiety to the solvent.
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(as it appears on PubMed at http://www.pubmed.gov), where 16603129 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16603129}}
==About this Structure==
==About this Structure==
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[[Category: Yamashita, E.]]
[[Category: Yamashita, E.]]
[[Category: Hydorolase metalloprotease]]
[[Category: Hydorolase metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 23:31:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:52:18 2008''

Revision as of 19:52, 28 July 2008

Template:STRUCTURE 2d1n

Collagenase-3 (MMP-13) complexed to a hydroxamic acid inhibitor

Template:ABSTRACT PUBMED 16603129

About this Structure

2D1N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453., Kohno T, Hochigai H, Yamashita E, Tsukihara T, Kanaoka M, Biochem Biophys Res Commun. 2006 May 26;344(1):315-22. Epub 2006 Mar 27. PMID:16603129

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