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2jqd

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{{STRUCTURE_2jqd| PDB=2jqd | SCENE= }}
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'''Structure of the Leucine-Rich Repeat domain of LANP'''
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===Structure of the Leucine-Rich Repeat domain of LANP===
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==Overview==
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The leucine-rich repeat acidic nuclear protein (Anp32a/LANP) belongs to a family of evolutionarily-conserved phosphoproteins involved in a complex network of protein-protein interactions. In an effort to understand the cellular role, we have investigated the mode of interaction of Anp32a with its partners. As a prerequisite, we solved the structure in solution of the evolutionarily conserved N-terminal leucine-rich repeat (LRR) domain and modeled its interactions with other proteins, taking PP2A as a paradigmatic example. The interaction between the Anp32a LRR domain and the AXH domain of ataxin-1 was probed experimentally. The two isolated and unmodified domains bind with very weak (millimolar) affinity, thus suggesting the necessity either for an additional partner (e.g. other regions of either or both proteins or a third molecule) or for a post-translational modification. Finally, we identified by two-hybrid screening a new partner of the LRR domain, i.e. the microtubule plus-end tracking protein Clip 170/Restin, known to regulate the dynamic properties of microtubules and to be associated with severe human pathologies.
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{{ABSTRACT_PUBMED_18410380}}
==About this Structure==
==About this Structure==
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2JQD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA].
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2JQD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JQD OCA].
==Reference==
==Reference==
Structural bases for recognition of Anp32/LANP proteins., de Chiara C, Menon RP, Pastore A, FEBS J. 2008 Apr 10;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18410380 18410380]
Structural bases for recognition of Anp32/LANP proteins., de Chiara C, Menon RP, Pastore A, FEBS J. 2008 Apr 10;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18410380 18410380]
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The Anp32 family of proteins containing leucine-rich repeats., Matilla A, Radrizzani M, Cerebellum. 2005;4(1):7-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15895553 15895553]
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NMR assignment of the leucine-rich repeat domain of LANP/Anp32a., de Chiara C, Kelly G, Frenkiel TA, Pastore A, J Biomol NMR. 2007 Jun;38(2):177. Epub 2006 Dec 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17180445 17180445]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Transcriptional regulation]]
[[Category: Transcriptional regulation]]
[[Category: Tumor suppression]]
[[Category: Tumor suppression]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:56:09 2008''

Revision as of 19:56, 28 July 2008

Image:2jqd.png

Template:STRUCTURE 2jqd

Structure of the Leucine-Rich Repeat domain of LANP

Template:ABSTRACT PUBMED 18410380

About this Structure

2JQD is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural bases for recognition of Anp32/LANP proteins., de Chiara C, Menon RP, Pastore A, FEBS J. 2008 Apr 10;. PMID:18410380

The Anp32 family of proteins containing leucine-rich repeats., Matilla A, Radrizzani M, Cerebellum. 2005;4(1):7-18. PMID:15895553

NMR assignment of the leucine-rich repeat domain of LANP/Anp32a., de Chiara C, Kelly G, Frenkiel TA, Pastore A, J Biomol NMR. 2007 Jun;38(2):177. Epub 2006 Dec 16. PMID:17180445

Page seeded by OCA on Mon Jul 28 22:56:09 2008

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